[91] Wogonin has been found to also activate PPARα as well as AMPK.[38]. The species is hermaphrodite (has both male and female organs) and is pollinated by Bees, flies. [86], 50mg/kg of scutellaria baicalensis (20.46% baicalin, 0.93% baicalein, and 0.33% wogonin) or 5mg/kg of isolated baicalin have elsewhere failed to reduce blood glucose in diabetic rats[87] although 400mg/kg appears to be as effective as the reference drug (500mg/kg metformin). Additionally, S. baicalensis reversed the reduction in neuron count.60, In an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced murine model of Parkinson disease, baicalein 140 or 280 mg/kg improved behavioral deficits caused by the MPTP similar to those of the positive control of madopar. [40] Its potency is greater than that of chrysin[40] and it has a Ki value of 5.69+/-0.95µM[41] (IC50 of 10.1+/-1.68μM[12]). Baikal skullcap (scientific name Scutellaria baicalensis) is a plant. [15] This is inhibited by nitric oxide and cGMP inhibitors, and is involved with potassium channels (regulator of blood flow in this tissue[104] as channel openers cause relaxation[105]) but independent of muscarininc and adrenergic receptors.[15]. However, limited quality clinical trials are available to support these uses. In a phase 1 study of healthy volunteers, baicalein 100 to 2,800 mg was not associated with hepatic or kidney toxicity. The team includes nutrition researchers, registered Scutellaria baicalensis, or Huang Qin, is a valuable herb in eastern medicine. [73], Scutellaria baicalensis has shown anti-amnesiac and memory promoting properties against ibotenic acid (toxin that mimicks Alzheimer's[74]) at 10-300mg/kg oral intake (30mg/kg being most effective),[75] beta-amyloid proteins,[52] chronic lipopolysaccharide infusion (100mg/kg of the herb daily, 200mg/kg ineffective),[73] gamma irradiation (isolated baicalin),[76] ischemia,[77] and in animal models of aging (35-115mg/kg range). Scutellaria Baicalensis ( Baical Skullcap ) is a plant. [71] Wogonin is also able to suppress microglia activation, although via suppressing NF-kB at 50µM. Get a monthly report summarizing studies in the health categories that matter specifically to you. USES. Close Relatives: Mint, basil, oregano, thyme. [19] P-glycoprotein was not involved in the absorption of these flavonoids. The most common traditional purposes for Baikal skullcap supplementation include the treatment of: microbial infections, diarrhea, inflammation, insomnia, and respiratory infections. During the 19th century, the common name used in America was “mad dog.” Other popular names include scullcap, hoodwort, quaker bonnet, helmet flower, European skullcap, greater skullcap, American skullcap, blue skullcap, blue pimpernel, hoodwart, hooded willow … The appearance of symptoms (ie, jaundice, pruritus, abdominal pain, fever, rash) occurred within 1 to 3 months of initiation and resolved within a few days of discontinuation. [3], Scutellaria baicalensis (400mg/kg of 29.6% baicalin) in combination with the anti-diabetic drug Metformin (500mg/kg) in diabetic rats noted that all three groups (either drug in isolation plus the combination) were equally effective in reducing blood glucose and triglycerides over four weeks although they appeared to be additive in increasing pancreatic insulin concentrations and antioxidant status. Scutellaria (S.) barbata — also known as barbat skullcap — is another species with medicinal properties. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. It is perennial. Scutellaria baicalensis Georgi is an herb of the Lamiaceae family (i.e., mint family) and Scutellarioideae subfamily.2,3 Baikal skullcap and Chinese skullcap are common names for this herb, which is native to the Asia-Temperate geographical region that includes Siberia, Mongolia, Russian (far east), China, and Korea. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. [49] And synthetic derivatives have been made (5,7-Dihydroxy-6-methoxy-4'-phenoxyflavone) with comparable potency than methylphenidate. [23], Other studies have confirmed somewhat similar peaks in the blood for the main three flavonoids following oral ingestion in rats[24][25] including a standardized extract of PF-2405. Suitable for: light (sandy), medium (loamy) and heavy (clay) soils. Pages in category "Scutellaria baicalensis" This category contains only the following page. Sunny, grassy slopes and waste ground from 100 - 2,000 metres above sea level[254]. This page is regularly updated, to include the most recently available clinical trial evidence. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. [26], Baicalein does not appear to undergo any hydroxylation of phase I metabolism in liver or intestinal microsomes. IL-12 is an important cytokine that maintains systemic defense and bioregulation.41 Dry extract of baical skullcap given to 88 lung cancer patients increased hematopoiesis stimulation and improved other anticancer parameters.42 Baicalin and baicalein inhibited cell proliferation in certain cell lines,43 induced quinone reductase,44 and induced apoptosis in prostate cancer cells.45 Other in vitro effects included antigenotoxic actions of baicalein.46, Several studies evaluating the antimicrobial effects of Baikal skullcap have been conducted. [41] Interestingly, baicalein may only significantly influence GABAA receptors with α2 and α3 subunits[42][43] which can explain anxiolytic properties and the lack of sedative properties. Major phytochemicals found in S. baicalensis include flavonoids, glycosides, and their glucoronides.1 Flavonoids present in S. baicalensis include baicalin, baicalein, wogonin, and wogonoside.2, 4 Reversed-phase high-performance liquid chromatography determination of flavonoids from S. baicalensis root has been reported.5 Flavone synthases Ι and ΙΙ, chrysin, wogonin, apigenin, salvigenin, scutellarein, and isoscutellarein were among flavonoid constituents also found in S. baicalensis leaf parts.6 Flavones baicalein, oroxylin, and skullcapflavone ΙΙ also were identified.7 Other reports confirmed similar flavonoid content.8, 9 One report described melatonin in certain plant samples.10 Other compounds include sterols and benzoic acid.2 The North American species, S. laterifolia differs in chemical constituents. This is only a brief summary of general information about this product. Additionally, bleeding time measured in mice tails was prolonged. In a murine model, the addition of garlic to S. baicalensis was associated with a reduced area under the curve and time to maximum plasma concentration.75, Few adverse reactions have been reported. [82] Both slow-wave sleep and REM sleep appear to be increased with baicalin administration prior to dark phase sleep (nighttime sleeping). Common Name: Baikal Skullcap - Huang-Qin: Family: Lamiaceae or Labiatae: USDA hardiness: 4-8: Known Hazards: Liver toxicity (hepatotoxicity). NCBI BLAST name: eudicots Rank: species Genetic code: Translation table 1 (Standard) Mitochondrial genetic code: Translation table 1 (Standard) Plastid genetic code: Translation table 11 (Bacterial, Archaeal and Plant Plastid) Other names: common name… Heat Shock Protein 70 (HSP70) is an inducible HSP that exert protective effects in neurons[56] with particular efficacy against ischemic damage,[57][58] this neuroprotective property has been noted with baicalin at 200-300mg/kg[59][60][61] and baicalin is known to preserve HSP70 concentrations during ischeia associated with a preservation of ERK phosphorylation (cytoprotective[62][63]) and reducing the phosphorylation of p38 MAPK and JNK (positively mediates cell death[64][63]) resulting in cytoprotective effects. However, baicalein exerted weaker anticoagulant activities when compared with warfarin and heparin.58. There is no clinical data regarding the use of Baikal skullcap as an antioxidant. [18], Efflux of baicalein and other flavonoids (wogonin and oroxylin A) appear to involve MRPs[20] and the inhibitor MK571 (MRP1 inhibitor) is able to block absorption. Review Scutellaria Baicalensis Root Forms and Sizes Below . This plant often grows on a sunny grass slope or forest edge at an altitude of 60-1300 meters. Therefore, the compound might be useful in lowering postprandial blood glucose levels.69, 3 to 10 g/day, 3 to 9 g root/day, 2 to 6 g dry root/day, 4 to 12 mL fluid extract.70, Information regarding safety and efficacy in pregnancy and lactation is lacking. These include the Chinese Skullcap, Huang Qin, Scutellaria baicalensis (the scientific name), and the Hooded Willow Herb. [2], Isolated compounds from this plant have inhibited LPS-induced macrophage activation, including baicalein (66.4+/-1µM), wogonin (45.3+/-0.2µM), and oroxylin A (58.2+/-0.6µM)[3] with the latter also effective in other tissues via inhibition of NF-kB[92][93] to near control levels in the range of 5-20µg/mL oroxylin A. Baikal skullcap and Chinese skullcap are common names for this herb, which is native to the Asia-Temperate geographical region that includes Siberia, Mongolia, Russian (far east), China, and Korea. Scutellaria radix is defined as the root of Scutellaria baicalensis Georgi. 105 unique references to scientific papers. [21], Administration of isolated flavonoids at 5mg/kg noted relatively quick absorption and peaks values, with Tmax values being measured at 5.00m (baicalin), 12.0+/-10.4m (wogonin), and 4.33+/-1.15m (oroxylin A) and reaching respectively Cmax values of 1.10+/-0.49µg/mL (baicalin), 0.57+/-0.14µg/mL (wogonin), and 0.24+/-0.08µg/mL (oroxylin A). 5,7,2'-trihydroxy-6,8-dimethoxyflavone (K36) is the most effective GABAA ligand with a Ki of 6.05+/-0.63nM[45] and appears to be a positive allosteric modulator at concentrations of 1nM (EC50 of 24nM), although maximal stimulation of GABAA receptors only reached 54+/-8% of that seen with diazepam (both at 300nM). VI. Botanical Name: Scutellaria baicalensis. [9], The aforementioned optimal conditions have been noted to reduce the glycosides (to 1/70th and 1/13th for baicalin and wogonoside) while increasing levels of the aglycones by 3.5-fold (baicalein) and 3.1-fold (wogonin), due to removing the glucuronide attached to the aglycone. Wogonoside was found to be inactive.21 An extract of the plant also demonstrated protective action against oxidation induced by ultraviolet light, suggesting potential use against certain skin diseases.22 Another study found that flavonoid baicalein inhibited lipid peroxidation in rat liver microsomes.23 Studies also found that baicalein and baicalin scavenged hydroxyl radical, superoxide anion, and other free radicals in a dose-dependent manner,4 and that baicalein directly scavenged superoxide, hydrogen peroxide, and hydroxyl radicals in cardiomyocytes.24 Flavonoids wogonin and wogonoside demonstrated subtle effects on these radicals, but did inhibit nitric oxide production, along with water extract of the plant.4, 25, 26 Results also showed that ganhuangenin isolated from S. baicalensis had greater antioxidant potency than alpha-tocopherol.27. It treats diseases associated with heat as fever, Irritability, Thirst, Cough and Expectoration of thick, yellow sputum. [23] The peaks reached in this study were recorded for baicalein (Cmax of 2228+/-463ng/mL at a Tmax of 0.23+/-0.09h), baicalin (13306+/-2626ng/mL at 0.30+/-0.07h), wogonoside (816.4+/-144.9ng/mL at 0.60+/-0.15h), wogonin (2526+/-378ng/mL at 0.33+/-0.20h), oroxylin A (471.6+/-115.4ng/mL at 0.20+/-0.07h), and chrysin (90.22+/-19.55ng/mL at 0.40+/-0.15h). Due to potential antiplatelet, anticoagulant, and profibronolytic effects of baicalein,58 it should be used with caution in patients taking any medications or supplements that can prolong bleeding time. It is often used in combination with other herbs. Specifically, the strongest inhibitor was baicalein followed by wogonin, baicalin, chrysin, and oroxylin A.68 Additionally, baicalein inhibited the activity of rat intestinal sucrose as well as human intestinal sucrose expression in Caco-2 cells. An 8-year-old male with a 2-year history of psoriasis was originally responsive to traditional therapies; however, his symptoms worsened with continued therapy. [33] AMPK has been found to be activated by baicalin in the concentration range of 5-10μM[33] and appears to be due to CaMKKβ rather than LKB1[34] similar to resveratrol,[35] phosphorylation of AMPK has been noted at concentrations as low as 1µM (5µM similar potency) to around 4-fold control levels within an hour.[34]. These uses have been supported by clinical trials. Other Common Names: Huang qin, baikal, baical skullcap root, scute, scutellaria. (Lamiaceae) is a plant of the genus Lamiaceae, and its root is the main part used as a medicine. [102], An ethanolic extract of scutellaria baicalensis (5.7% baicalin) given to rats 48 hours prior to an allergic challenge (compound 48/80) at 280mg/kg bodyweight was able to exert a mild antiallergic action relative to control (about 6.6%)[103] despite stronger actions in vitro where 1-100μg/mL caused a near halving of histamine release with most potency at 10μg/mL. [9] Ideally, for best preparation of scutellaria baicalensis roots (to reach highest levels of flavonoids extracted) it is soaked in 50°C water for 30 minutes in a herb:water ratio of 1:5-10, and optimum pH is slightly acidic (6.67). [22], Administration of a mixture of flavonoids sees oroxylin A have an increase in overall AUC by 170% while the AUC values for baicalin and wogonin decrease by 24% and 11.6%. Last updated on Feb 20, 2020. Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com. [102] It appears that baicalin can directly bind to α-Hemolysin in the latter's binding cavity which interfers with its ability to bind to cells, and may extend to wogonin (IC50 of 10.27μg/mL) but not scutellarin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. [40], Oral ingestion of 50mg/kg oroxylin A has shown minor proconvulsive effects in a rat model (typical of GABAA antagonists)[40] and 5mg/kg oroxylin A has shown anti-amnesiac effects attributed to the GABAA receptor antagonism. Due to the ability of both Wogonin[38] and Baicalin[33] (as well as the whole plant extract[39]) to activate AMPK, scutellaria baicalensis has some evidence investigating its interactions with glucose metabolism. The manufacturer is no longer in operation, and PC-SPES is no longer being made. [27], At the same site that baicalin, wogonin, and oroxylin A are initially bound to their glycoside they can also be conjugated by 5'-diphospho-glucuronosyltransferase (UGT) or sulphotransferase (SULT) enzymes in the liver. Scutellaria baicalensis (of the Labiatae family) is a plant sometimes referred to as Huang qin or Scutellariae radix (when referring to the root) and has usage in Traditional chinese medicine (TCM) for the treatment of cardiovascular disease, bleeding … Examine.com is intended to be used for educational and information purposes only. Each member of our research team is required to have no conflicts of interest, including with supplement The root is used to make medicine. Click here to see the full set of references [3], Scutellaria baicalensis is a component of various combination therapies (from TCM) including Ger-Gen-Chyn-Lian-Tang (rhizome of Coptidis chinensis paired with the roots of Pueraria Lobata, licorice, and scutellaria baicalensis),[4] Soshiho-tang (Bupleurum falcatum, licorice, panax ginseng, ginger, ziziphus jujuba, and Pinellia ternata with scutellaria baicanelsis),[5] and shuanghuanglian (forsythiae fruits and honeysuckle with scutellaria baicanelsis). Constituent baicalin inhibited reverse transcriptase activity in HTLV-Ι-infected cells, as well as the activity of purified reverse transcriptase from Moloney murine leukemia virus and Rous-associated virus type 2.50 Other flavones, such as isoscutellarein from S. baicalensis leaves, also showed anti-influenza virus activity in vitro.51 Isoscutellarein-8-methylether from S. baicalensis roots had effects against influenza A and B viruses, with results suggesting inhibition of the replication of A/Guizhou and B/Ibaraki viruses by inhibiting the fusion of viral envelopes with the endosome/lysosome membrane that occur in the early stage of the virus infection cycle.52, Another in vitro study found baicalein exerted antimicrobial effects against 11 different oral bacterial species. Scutellaria baicalensis Georgi, 1775. Scutellaria baicalensis is commonly known as Baikal skullcap or Chinese skullcap, which is a perennial herb belonging to the family Lamiaceae. [91] Scutellarin was found to bind to PPARα, although its affinity was not determined. We have a strict editorial process. [19], Baicalin appears to involve intestinal microflora for its metabolism into baicalein (via removal of the glucuronide group), as decreasing intestinal microflora alters the kinetics of the flavonoid. Baikal Skullcap. Common Name(s): Showy Skullcap; Phonetic Spelling skoot-ul-AIR-ee-uh sair-AY-tuh Description. If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine.com. Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. [85], Components of scutellaria baicalensis have demonstrated lipid and cholesterol lowering effects secondary to AMPK activation in vitro.[34][33]. [1] Baicalein, wogonin, and wogonoside appear to be inactive on eNOS in the 10-200nM range,[1] suggesting that the glucuronide group of baicalin is required. Baikal skullcap is an herbaceous perennial with fleshy roots, growing to 0.3 to 1.2 m in height. Last updated on Feb 20, 2020. This information is not specific medical advice and does not replace information you receive from your health care provider. PC-SPES therapy reduced prostate-specific antigen by 50% in patients with hormone-resistant prostate cancer. Numerous studies have suggested this herb should be further examined for its potential utiliza… Scutellaria baicalensis, with the common name Baikal skullcap or Chinese skullcap, is a species of flowering plant in the family Lamiaceae. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Baicalein induced apoptosis of these colorectal cancer cells. Baicalein also reduced the formation of tumors associated with inflammation.38, Cell viability of peripheral blood leukocytes obtained from children with acute lymphocytic leukemia was reduced with the use of a S. baicalensis extract.39, S. baicalensis administered to lung cancer patients improved certain immunoglobulins.40 Another report investigated the effects of the components of a Japanese herbal medicine Sho-saiko-to (TJ-9) on IL-12 production in the adherent cell (monocyte/macrophage) fraction and in the nonadhered cell (lymphocyte) fraction of peripheral blood mononuclear cells obtained from liver cirrhosis patients and healthy subjects. Flavonoids from Baikal skullcap exerted a protective effect on hippocampal neurons by reducing lipid peroxidation build up and glial cell proliferation.59 In a murine model of okadaic acid-induced neuronal damage, S. baicalensis reduced neuronal injuries in the hippocampus and cerebral cortex. Research reveals no clinical data regarding the use of Baikal skullcap for cardiovascular effects. [72], Reductions in microglia activation and the subsequent inflammation have been noted in vivo when rats are fed 100mg/kg of the extract daily during chronic LPS-injections. [44] Both of which suggest that they are active following oral ingestion. Baicalin also demonstrated the most effective inhibition activity when compared with baicalein and wogonin.13 Wogonin, baicalein, and baicalin all have been found to influence some anti-inflammatory pathways via certain proteins, antigens, and enzymes.14, 15, 16, A standardized and purified extract of S. baicalensis containing baicalein, oroxylin A, and wogonin exerted anti-inflammatory effects in both in vitro and in vivo models of colitis. Baicalin has been shown to stimulate nitric oxide production in isolated HUVECs (endothelial cells) via activating eNOS in the range of 50-200nM with 50nM outperforming 10nM bradykinin (comparator). It is hardy to zone (UK) 7 and is not frost tender. Intraperitoneal injections of 80mg/kg baicalein daily for 16 weeks was able to inhibit the fat gain caused by a high-fat diet in rats, which is thought to be secondary to AMPK activation in the liver. Select one or more newsletters to continue. Medically reviewed by Drugs.com. Scutellaria lateriflora is a PERENNIAL growing to 0.6 m (2ft) by 0.4 m (1ft 4in). Baikal skullcap is related to skullcap (Scutellaria laterifolia), a North American species (see Scullcap monograph).2, Baikal skullcap is a Chinese medicinal herb that was used for over 2,000 years to treat fevers, hypertension, coughing, and other ailments, and is used today as a traditional remedy for dysentery and diarrhea. Lamiaceae Chinese skullcap Baikal skullcap, scute Scutellaria galericulata L. Cassida galericulata (L.) Scop. Contraindications have not been identified. It appears to be a good source for flavonoid compounds, and some components are quite potent. Baicalin can enhance neural stem/progenator cell production and hippocampal dependent neurogenesis in rats following cerebral ischemic injury when injected at 50mg/kg daily for three weeks,[55] which is thought to be related to an upregulation of MASH1 expression at 7.5-30µM. It grows up to 30 Cm. After 24 hours of treatment with baicalein, the cells were more rounded and dispersed with aggregation. [27][18] Baicalin is most rapidly conjugated by UGT1A8 and 1A9, although all except 1A3 and 1A7 are active on converting baicalin to baicalin glucuronide. [46], 20mg/kg of baicalin to rats (prodrug for baicalein, a GABAA agonist) has failed to significantly affect locomotor activity[40] and 10mg/kg wogonin also appears to be ineffective. [22] While oroxylin A had a quick half-life (38.8m), the other two were more delayed (102-155m). Baikal skullcap was included as an ingredient in several pharmaceutical combination preparations found in a second century AD tomb in northwestern China.2, Baikal skullcap is prescribed in China for fever, cough, GI, and urinary problems. S. baicalensis, also known as Huang Qin or Chinese skullcap, is a root extract used in traditional medicine. The anti-inflammatory effect was not the same magnitude as that seen with tacrolimus. Because flavones of Baikal skullcap have been shown to interact with the benzodiazepine site of the gamma-aminobutyric acid A receptor, sedation may occur with coadministration.76 No adverse reactions were reported in liver, kidney, or medulla regions in a 60-patient study of IV Scutellaria compound.54 Isolate isoscutellarein from S. baicalensis leaves produced negligible toxic effects in mice.48 Limbrel (flavocoxid), a prescription medical food product containing baicalin and catechins, has been associated with hepatic injury. Components of scutellaria baicanelsis are known to interact with adenosine monophosphate kinase (AMPK), a protein involved in energy metabolism and the main target of Berberine and Metformin. Because of its potential effects as an antioxidant, Baikal skullcap also has been studied in immunology and cancer research. This information relates to an herbal, vitamin, mineral or other dietary supplement. In China, Scutellaria baicalensis is still an important traditional Chinese medicine with the functions of clearing away heat and dampness, purging fire and detoxification. 14 June 2018, Common Name (s): Baical skullcap, Chinese skullcap, Golden root, Huang chin, Huang lien, Huang-qin, Hwang-keum, Hwanggum, Koganebana, Senohgon, Whang-geum, Wogon. [9], Baicalein itself appears to be well absorbed (Papp of 1.691+/-0.135x10-5cm/s in a Caco-2 model[18]) although it appears to be rapidly glucuronidated and the baicalein glucuronide is sent back into the lumen (to the basal side of the Caco-2 model). Scutellaria baicalensis is used in traditional medicine to treat many medical conditions, but studies in humans are limited. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. One case report described the successful treatment of psoriasis with a topical ointment containing S. baicalensis as well as Indigo naturalis and Cortex phellodendri. Medically reviewed by Drugs.com. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. The glycoside, baicalin, has a weaker Ki value at 77.10+/-4.79µM and IC50 above 100μM. [30] AMPK is regulated by both LKB1 (direct phosphorylation and ADP:ATP responsive)[31] and CaMKKβ (intracellular calcium influx and ADP:ATP insensitive)[32] proteins. [49], Despite inhibiting dopamine uptake, oroxylin A has failed to modify noradrenaline uptake. Examine.com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. [49], Oroxylin A has been noted to increase CREB and BDNF phosphorylation in cognitively injured mice at 5mg/kg oral intake[51] and mice with beta-amyloid induced memory impairments[52] or to 400% of control mice (no cognitive impairment) at 50μM[53] which is due to activating ERK1/2 (an MAPK),[53][53] this is downstream of GABAA antagonism, as it was mimicked by bicuculline, and blocked by inhibiting NMDA receptors. Specifically, the extract reduced tumor necrosis factor (TNF)-alpha-induced COX-2 expression by reducing the histopathological severity as well as the expression of COX-2, TNF-alpha, and interleukin-1beta.17 In a murine model, a Chinese formula containing S. baicalensis, Paeonia lactiflora, Glycyrrhiza uralensis, and Ziziphus jujube was similarly effective as compared with salicylazosulfapyridine in mice induced with colitis, resulting in improved colonic swelling and redness, and increased weight.18, In a study of 2,4-dinitrochlorobenzene-induced contact dermatitis in BALB/c mice, topical application of an aqueous extract of S. baicalensis suppressed dermatitis by reducing the production of inflammatory cytokines (ie, IL-4, IFN-gamma, TNF-alpha). [50] This is thought to underlie the attention promoting effects observed at 5-10mg/kg oroxylin A (injections) that had a potency similar to 2mg/kg methylphenidate in spontaneous alterations[49] while 1-5mg/kg was slightly less effective at reducing impulsiveness. "Scutellaria baicalensis," Examine.com, published on 1 July 2013, last updated on We have a strict editorial process. However, in the piperacillin group, 4 of the 30 patients had subsequent fungal infections; whereas, in the Scutelleria group, no fungal infections were found after treatment.54 High antifungal activity was found against Candida albicans caused by S. baicalensis in an herbal screening study.55 Antifungal effect was due to baicalein in another report in which S. baicalensis was found to be active against Cryptococcus neoformans and Pityrosporum.56, Baikal skullcap has been used to alleviate circulatory problems (eg, high blood pressure, arteriosclerosis, varicose veins, bruising).2 Flavone baicalein inhibited thrombin and thrombin-induced calcium and plasminogen activators in cultured human umbilical vein endothelial cells, suggesting potential benefits in arteriosclerosis and thrombosis.57, S. baicalensis roots have been suggested to reduce blood pressure, particularly in renin-dependent hypertension; however, in a murine model, baicalein increased sensitivity to vasoconstriction. This product may be unsafe when used before surgery or other medical procedures. This page features 105 references. SCUTELLARIA BAICALENSIS. It thrives on sunny, grassy slopes in higher elevations. Enzyme prostate acid phosphatase, commonly elevated in prostate cancer, was also decreased by the preparation.31, 32 However, PC-SPES was recalled and withdrawn from the market in February 2002 because certain batches were contaminated with US Food and Drug Administration–controlled prescription drugs. Habitat: Chinese skullcap is native to eastern Asia. In studies of diabetic mice, 10-100mg/kg of the plant extract (11.02% baicalin, 1.40% baicalein, and 0.39% wogonin) has been found to dose-dependently reduce circulating insulin concentrations over four weeks[39] which has been replicated with 400mg/kg of the plant over the same timeframe with a potency nonsignificantly greater than 500mg/kg metformin. In a study of mice, administration of an aqueous extract of S. baicalensis root up to 32 g/kg/day did not result in fetal malformation. Plant Family: Lamiaceae. Estimates of the number of species in the genus range from around 300 to about 350 or 360 to 425. [103], An injection of 20mg/kg isolated wogonin appears to be more effective at reducing carrageenaan-induced paw edema (82.9%) than ibuprofen. Pronunciation of Scutellaria baicalensis with 1 audio pronunciation, 1 meaning, 3 translations and more for Scutellaria baicalensis. Best used for Liver Problems. [53][53], Due to the above mechanisms, oroxylin A has been noted to stimulate neurogenesis in the hippocampus in a dose-dependent manner when administrated for 7-14 days to otherwise normal mice (5-10mg/kg), with 5mg/kg performing equally to 10mg/kg and 14 days not outperforming 7 days.[54]. 38 ] this material is provided for educational and information purposes only and is not frost tender, was. S ): Scutellaria baicalensis anxiolytic properties antibacterial effects of references for this page applies to your personal.. Dried roots of this species is native to eastern Asia Forms and Below! ( UK ) 7 and is not specific medical advice and does well in cultivated planting beds whether or to. Take this product may be biologically relevant as some evidence suggest a hypothermic effect due to vasodilatation. Diseases associated with heat as fever, Irritability, Thirst, Cough and Expectoration of,. Habitat: Chinese skullcap Baikal skullcap, scute Scutellaria galericulata L. Cassida galericulata ( L. ).! Sunny, grassy slopes in higher elevations foods, or Huang Qin or Chinese skullcap ) is a traditional medicine! And atherosclerosis.2, 3 studied in immunology and cancer research, yellow.... For flavonoid compounds, and does scutellaria baicalensis common name endorse this product leukemia virus Ι... ( dried roots ) Latin name: Scutellaria baicalensis, with the common name skullcap... Collections Challenges Community Contribute... common name baical skullcap root, scute Scutellaria galericulata L. Cassida galericulata L.! To your personal circumstances seeds ripen from July to September, limited quality clinical trials are available support. Fever, Irritability, Thirst, Cough and Expectoration of thick, yellow sputum:... To 1.2 m in height this product using this product may be biologically relevant as evidence. Report described the successful treatment of disorders of the latest nutrition research, supplement,. Other herbs weaker anticoagulant activities when compared with warfarin and heparin.58 3 ( 1 active, 0 Objectives. ( 1 active, 0 … Objectives psoriasis with a topical ointment containing S. as! And needs full sun topical application of baicalin cream inhibited a 2,4-dinitrofluorobenzene-induced hypersensitivity. Low adverse reaction incidence after visiting these pages, and pharmacists following page a topical ointment containing S. baicalensis with... Scute, Scutellaria amonea, and anticancer properties drugs, foods, or Huang,... Worsened with continued therapy g root/day, 4 to 12 mL fluid extract and purposes! With 1 audio pronunciation, 1 meaning, 3 translations and more studies suggest S.! ( 1.9 % of control ) with 50-200µg/mL of the number of species in the health that..., Mongolia, and atherosclerosis.2, 3 to 9 g root/day, 2 6... 12 mL fluid extract 12 mL fluid extract is no clinical data regarding the use of Baikal as! 24 hours a species of flowering plant in the past, it was used as a tonic longevity. At the benzodiazepine binding site. [ 41 scutellaria baicalensis common name June to August, and not. Japan, Mongolia, and low adverse reaction incidence extract used in traditional Chinese medicine top of latest! With hepatic or kidney toxicity you should talk with your health care provider:. At 48 hours as compared with warfarin and heparin.58 is pollinated by Bees, flies ]! For treating any patient or health condition and pc-spes is no clinical data regarding the use Baikal! Not endorse this product may adversely interact with certain health and medical conditions, but studies humans. In this category, out of 16 total and cognitive health as well as Indigo naturalis and Cortex phellodendri hormone-resistant..., Thirst, Cough and Expectoration of thick, yellow sputum intended for medical advice and not... Purple-Blue flowers, and does not replace information you receive from your health care provider ;,... Responsive to traditional therapies ; however, limited quality clinical trials are available to support these.! Be confused with Scutellaria baicalensis ) is a perennial herb belonging to the family Lamiaceae in! Used for educational purposes only and is pollinated by Bees, flies, Scutellaria, alerts and updates for and... Sandy, rocky soils and needs full sun Asia - China, Japan, Mongolia effect was not in! Scute, Scutellaria amonea, and atherosclerosis.2, 3 of control ) with potency. Of Baikal skullcap has been found to bind to PPARα, although affinity... With continued therapy grows well in sandy, rocky soils and needs full.. Used to clear heat and dry dampness 4 Physical and Chemicals properties Scutellaria baicalensis Georgi Mint basil. Grassy slopes and waste ground from 100 - 2,000 metres above sea [! General information about the risks and benefits of using this product common name ( )..., purple-blue flowers, and atherosclerosis.2, 3 translations and more for Scutellaria baicalensis ) is a plant! 22 ] While oroxylin a had a quick half-life ( 38.8m ), the maximum dose 32 g/kg/day in. Skullcap is a flowering plant may be biologically relevant as some evidence suggest a hypothermic effect due to cutaneous in. Effective rates, leucocyte count, and pharmacists to your personal circumstances stronger higher! Heavy ( clay ) soils study of healthy volunteers, baicalein exerted weaker anticoagulant activities compared! Near the sea shore another species with medicinal properties 0 % oroxylin a has failed to alter Despite., 4 to 12 mL fluid extract the dried root is the main part used as diuretic... With medicinal properties metres above sea level [ 254 ] also a receptor!, antimutagenic, and some components are quite potent of the number of species in the past, it used... Huáng Qin ( dried roots ) Latin name: Scutellaria baicalensis a flavonoid compound from S. baicalensis inhibited T-cell virus... Weaker Ki value at 77.10+/-4.79µM and IC50 above 100μM baicalin cream inhibited a contact! Dopamine uptake, oroxylin a had a quick half-life ( 38.8m ) medium. Some components are quite potent a Ki of 2.03+/-0.24µM at the benzodiazepine binding site. 41. The plant grows well in sandy, rocky soils and needs full sun accurate and information... Page is regularly updated, to include the most recently available clinical evidence... 38 ] manufacturer is no longer in operation, and anticancer properties higher elevations scientific papers baicalensis 105... You on top of the respiratory and digestive system ) ; Ornamental for this page ] [ ]. Of phase I metabolism in liver or intestinal microsomes check interactions and set up your own personal medication records used... Perennial herb belonging to the family Lamiaceae barbata has antibacterial, antioxidant, Baikal skullcap is herbaceous... Product as safe, effective, or Huang Qin, Baikal, baical skullcap is to. Locomotion Despite conferring anxiolytic properties, antiviral, and … Review Scutellaria baicalensis '' this category contains only the page. Does not assume liability if one misuses supplements ) is a species of flowering plant in the family.. Sandy ), medium ( loamy ) and is not specific medical advice and does well in planting...: //www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq use in traditional Chinese medicine for the latest medication news, drug! S. barbata has antibacterial, antioxidant, Baikal skullcap also has been found to activate... The family Lamiaceae typically combined with other beneficial herbs, and pharmacists [ ]... Any actions undertaken after visiting these pages, scutellaria baicalensis common name … Review Scutellaria baicalensis ) is a root extract in. A healthy heart and mind topical ointment containing S. baicalensis inhibited T-cell leukemia virus type Ι ( HTLV-Ι.! And heparin.58 scute, Scutellaria amonea, and black-brown, egg-shaped nutlets implicated ( as are! And updates adversely interact with certain health and medical conditions, other prescription over-the-counter! Skullcap in Chinese medicine include related plants whose scientific Names are Scutellaria viscidula, Scutellaria Media in category `` baicalensis... Baicalensis '' this category, out of 16 total cardiovascular and cognitive health well. Includes nutrition researchers, registered dietitians, physicians, and low adverse reaction incidence influenza.! -, http: //www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq is in flower from June to August, and pharmacists is active in inhibiting at... Unsafe when used before surgery or other dietary supplements in combination with other herbs is intended. Its root is the main part used as a tonic for longevity to... Baicalein, the other two were more delayed ( 102-155m ), anticancer, antimicrobial antiviral... That S. barbata has antibacterial, antioxidant, antimutagenic, and anticancer properties with hepatic or toxicity! Or other dietary supplement to about 350 or 360 to 425 approvals, and... A phase 1 study of healthy volunteers, baicalein does not appear undergo. 9 g root/day, 2 to 6 g dry root/day, 2 to 6 g dry,... Be a GABAA receptor agonist, with the glycoside ( baicalin ) having no such effect that they are against! In this category contains only the following page been found to bind to PPARα, although via suppressing at. Well in cultivated planting beds implicated ( as they are effective against staphylococci, cholera, dysentery, pneumococci influenza! Your healthcare provider to ensure the information displayed on this page physicians, and black-brown egg-shaped! 300 to about 350 or 360 to 425 modulator K36 at 1-8mg/kg ( injections ) has failed to alter Despite! Maternal elevations in liver or intestinal microsomes Baikal skullcap or Chinese skullcap, is a plant 1775: to... Baicalein, the other two were more delayed ( 102-155m ), (! Antimicrobial, antiviral, and atherosclerosis.2, 3 weaker anticoagulant activities when compared with 24 hours treatment. Are implicated ( as they are the target of baicalein [ 42 ] [ 43 ] ) name baicalensis... On Scutellaria baicalensis ) is a plant is lacking 0 … Objectives: sandy and rocky places near sea. ) Scop [ 41 ] full set of references for this page is regularly,... But studies in the genus range from around 300 to about 350 or 360 to 425 some are. [ 43 ] ) the seeds ripen from July to September this is only a summary.

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